The Pocket LOOX 410 and 420 measure 4.5 x 2.8 x 0.6 in (11.3 x 7.1 x 1.4 cm) and weighs 4.4 ounces (125 grams).

While both models support Bluetooth, the Pocket LOOX 420 also supports Wi-Fi (802.11b) wireless networking. The Pocket PCs' transflective TFT supports the usual Pocket PC resolution of 240 x 320 pixels with a 65,536 colors.

The Pocket LOOX 400 Series employs 300 MHz and 400 MHz Intel XScale PXA 255 processors in the Pocket LOOX 410 and Pocket LOOSX 420 respectively, together with Microsoft’s Windows Mobile 2003 operating system, and not the more recent Second Edition version of the platform. Both handhelds include 64MB of RAM. For memory and peripheral expansion, they integrate a SDIO-enabled Secure Digital slot.

Both models run on a 1100 mAH Lithium-Ion battery that is removable for up to 10 hours of power. When exchanging the battery for a optional spare battery, users have a 30 minute window in which to do so without losing their data.